Sonomechanics Blog

One of the most common questions we receive from customers is about the long-term stability of nanoemulsions made with our All-In-One NanoStabilizer® systems—both the liquid (LT) and powdered (LSO) formats—when used with our ultrasonic processors (lab-, bench-, orindustrial-scale) or third-party high-pressure homogenizers. Specifically, customers want to know how well droplet sizes hold up over time, which is key to maintaining the exceptional pharmacokinetic performance (high bioavailability and short onset times) these water-soluble formulations are known for.

The answer? Incredibly well.

All-In-One NanoStabilizers® have transformed the cannabis and nutraceutical industries by simplifying the creation of permanently stable, highly bioavailable nanoemulsions. These revolutionary products are designed to work with a wide range of poorly water-soluble bioactive ingredients, including full- and broad-spectrum oils, distillates, isolates, vitamins, essential oils, terpenes, alkaloids, and many more. Compatible with both high-pressure homogenizers (HPH) and ultrasonic processors, NanoStabilizers® ensure the industry’s smallest droplet sizes, superior stability, enhanced bioavailability, and rapid onset of action for your nano-formulations.

Producing fast-acting, highly bioavailable, readily water-soluble nanoemulsions of bioactive ingredients—such as cannabis extracts, pharmaceutical and nutraceutical compounds, vitamins, essential oils, and terpenes—has become standard practice for many functional food and beverage manufacturers. Whether crafting beverages, water-based tinctures, gummies, edibles, or other infused products, the ability to reduce the onset time and enhance the bioavailability of incorporated bioactives is critical. The key to achieving these outcomes lies in formulating nanoemulsions with sub-100 nm median droplet sizes [1, 2].

Industrial Sonomechanics (ISM), a global leader in high-intensity ultrasonic technology and nano-formulations, proudly announces that its all-in-one NanoStabilizer®-LSTM has successfully passed validation and is now available to companies seeking to produce liquid and powdered water-soluble kratom formulations from mitragynine-rich extracts. Already popular with functional beverage producers for water-soluble mushroom extracts, this innovative, all-natural formulation is now accessible to kratom product manufacturers. It enables the production of highly bioavailable, clean-label water-soluble mitragynine liquids and powders, opening new opportunities in the nutraceutical and supplement markets.

We are thrilled to announce the launch of NanoStabilizer®-LSTM, the newest addition to our product line!

Building on the success of our All-In-One NanoStabilizer®-LT and LSO, the Industrial Sonomechanics R&D team continues to push the boundaries of innovation in the production of water-compatible nanoemulsions. This new cutting-edge formulation is specifically designed to help you produce water-soluble liquids and powders from mushroom extracts, opening up new possibilities for the food, beverage, and supplements industries.

Industrial Sonomechanics® (ISM) has recently completed a groundbreaking pre-clinical pharmacokinetic study, comparing two orally administered Δ8-THC nanoemulsions (liquid and powdered) with a Δ8-THC solution in MCT oil. The results demonstrate considerable advantages of nanoemulsions produced with ISM's ultrasonic equipment and NanoStabilizers®, and are detailed in our latest manuscript, currently in press at AAPS PharmSciTech, an official journal of The American Association of Pharmaceutical Scientists.

This marks the industry's first pre-clinical study of Δ8-THC nanoemulsions, which was conducted and published in collaboration with Verdient Science, LLC.

We are excited to announce that Industrial Sonomechanics (ISM) will participate in the 2023 New England Cannabis Convention (NECANN) taking place on March 12th, 2023,  in Boston, MA. 

At this event, ISM President and Chief Scientific Officer, Dr. Alexey Peshkovsky, will deliver a keynote presentation entitled: "Water-Soluble" Cannabinoids, Alkaloids and Other Bioactives: Ultrasonic Production of Liquid and Powdered Nano-Formulations."

If you are interested in learning how to formulate and manufacture cannabis, kratom and other bioactives in the form of a water-soluble liquid or powder, please come to Dr. Peshkovsky's talk. 

We are excited to announce that Industrial Sonomechanics (ISM) will participate in the 2022 Wonderland event, taking place on November 3rd - 5th, 2022 in Miami, FL. At this event, ISM's President and Chief Scientific Officer, Dr. Alexey Peshkovsky, will join a panel discussion entitled: "Lab Science Behind the Magic". If you are interested in learning how to extract and formulate bioactive ingredients as water-soluble liquids or powders, please join us at this world's leading psychedelic event. 

We are excited to announce that Industrial Sonomechanics (ISM) will participate in the MJBizCon 2022, taking place on November 15 - 18, 2022, in Las Vegas, Nevada. 

At this event, our team will be showcasing ultrasonic processors (actually running them!), accessories & spare parts, NanoStabilizer® products and finished nano-formulations, so bring your team and join us at this largest cannabis convention of the year!

If you are interested in formulating and producing your own water-soluble liquid and powdered cannabis, kratom and/or other bioactives, please come see us at Booth 7937. 

We are excited to announce that Industrial Sonomechanics (ISM) will participate in the 2022 The Delta 8 + Conversions Expo in Partnership with The CBD Expo, taking place on October 6 - 7, 2022, in Orlando, FL. 

At this event, ISM President and Chief Scientific Officer, Dr. Alexey Peshkovsky, will deliver a keynote presentation entitled: "Water-Soluble" Cannabis, Kratom and Other Bioactives: Ultrasonic Production of Liquid and Powdered Nano-Formulations. 

If you are interested in learning how to formulate and manufacture cannabis, kratom and other bioactives in the form of a water-soluble liquid or powder, please come to Dr. Peshkovsky's talk.