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ISM Publishes a Groundbreaking PK Study of Two Δ8-THC Nanoemulsions

[fa icon="calendar"] Dec 19, 2023 1:00:00 AM / by ISM Team

Copy of Sonomechanics.comIndustrial Sonomechanics® (ISM) has recently completed a groundbreaking pre-clinical pharmacokinetic study, comparing two orally administered Δ8-THC nanoemulsions (liquid and powdered) with a Δ8-THC solution in MCT oil. The results demonstrate considerable advantages of nanoemulsions produced with ISM's ultrasonic equipment and NanoStabilizers®, and are detailed in our latest manuscript, currently in press at AAPS PharmSciTech, an official journal of The American Association of Pharmaceutical Scientists.

This marks the industry's first pre-clinical study of Δ8-THC nanoemulsions, which was conducted and published in collaboration with Verdient Science, LLC.

Nanoemulsions Outperform Oil Solution by 19X during 1 Hour and 4X during 4 Hours After Administration:


Main Study Aims and Design:

Over many years, ISM's ultrasonic equipment and NanoStabilizers® have enabled thousands of companies around the world to produce their own water-soluble liquid and powdered nano-formulations that can be infused into various finished products (beverages, edibles, water-soluble powder mixes, chewable and effervescent tablets, etc.) and significantly improve absorption profiles of the incorporated bioactive ingredients.

The main pharmacokinetic parameter of interest for most therapeutic ingredients (cannabinoids, alkaloids, terpenes, etc.) is the rate of absorption into the bloodstream post-administration. This rate is characterized as the "onset time", "time to maximum concentration in the bloodstream", and/or "average concentration in the bloodstream over a time window of interest".

This study was aimed at evaluating the rate of oral absorption of Δ8-THC formulated as two nanoemulsions: liquid translucent (made with NanoStabilizer®-LT) and powdered (made with NanoStabilizer®-LSO), and as an MCT oil solution. The study parameters were optimized for the rate of absorption evaluation, rather than other, less consequential parameters (absolute bioavailability comparisons, food effects, etc.).

liquid and powdered NEs

Summary of Results:

  • During the most important first hour after administration, NanoStabilizer®-LT- and LSO-based nanoemulsions provided 6x and 18.8x greater absorption of Δ8-THC, respectively, than the MCT oil solution.
  • During the extended 4-hour period after administration, NanoStabilizer- LT- and LSO-based nanoemulsions provided 1x and 3.4x greater absorption of Δ8-THC, respectively, than the MCT oil solution.
  • Both nanoemulsions enabled a much more rapid onset time and a much shorter time to maximum concentration in the bloodstream (~5 min and <1 hour, respectively) than the MCT oil solution (~1 hour and 6 hours, respectively).
  • The translucent liquid and powdered Δ8-THC nanoemulsions displayed remarkably similar properties to each other.

Main Conclusions: 

  • Δ8-THC nanoemulsions made with ISM's ultrasonic equipment and NanoStabilizers® allow consumers to quickly harness this cannabinoid's therapeutic effects, providing an almost immediate onset time and considerably greater absorption within time windows of interest.
  • ISM's nanoemulsions of hydrophobic active ingredients (cannabinoids, alkaloids, terpenes, etc.) are advantageous for creating fast-acting infused products, such as beverages, edibles, water-soluble powder mixes, chewable and effervescent tablets, and many others.

Download Manuscript


Have questions? Contact ISM at 1.786.233.9255 or


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Topics: Emulsion-based Products, General Announcements, Medical Cannabis