---
title: ISM Publishes a Groundbreaking PK Study of Two Δ8-THC Nanoemulsions
description: ISM publishes a groundbreaking PK Study of 2 Δ8-THC nanoemulsions. Nanoemulsions outperform oils by 19X during 1 hr & 4X during 4 hrs after administration.
image: https://blog.sonomechanics.com/hubfs/Copy%20of%20Sonomechanics.com.png
---

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# Sonomechanics Blog

## [ISM Publishes a Groundbreaking PK Study of Two Δ8-THC Nanoemulsions](https://blog.sonomechanics.com/blog/ism-publishes-a-groundbreaking-pk-study)

 \[fa icon="calendar"\] Dec 19, 2023 1:00:00 AM / by [ISM Team](https://blog.sonomechanics.com/blog/author/ism-team)

![](https://blog.sonomechanics.com/hs-fs/hubfs/logo%20icon%20sonomechanics.jpg?width=35&name=logo%20icon%20sonomechanics.jpg)

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![Copy of Sonomechanics.com](https://blog.sonomechanics.com/hs-fs/hubfs/Copy%20of%20Sonomechanics.com.png?width=243&height=243&name=Copy%20of%20Sonomechanics.com.png)Industrial Sonomechanics® (ISM) has recently completed a groundbreaking pre-clinical pharmacokinetic study, comparing two orally administered **Δ8-THC nanoemulsions** (liquid and powdered) with a **Δ8-THC solution** in MCT oil. The results demonstrate considerable **advantages** of nanoemulsions produced with ISM's ultrasonic [equipment](https://www.sonomechanics.com/3600_w_industrial-scale_processor/?utm_campaign=General%20Announcements&utm_medium=email&_hsmi=284194826&_hsenc=p2ANqtz-8YRCLNqQ7LgthUZOxlQveZrw9Hd8yFp873ednGSsSZJw9iTb9CXiY5_7_NNw6X2WmknGqOWUr9Qkmvur0gDcMRx_wrQw&utm_content=284194826&utm_source=hs_email) and [NanoStabilizers®](https://sonomechanics.myshopify.com/collections/all-in-one-nanostabilizer), and are detailed in our latest [manuscript](https://link.springer.com/epdf/10.1208/s12249-023-02699-1?sharing_token=S5QgmYKAqE_o2kaJ9Md2_pil69fZbNCDjUAQWCaB_PtowdNEYhuEkkxVS5QEajiRP2o9pxo2BOwjC_JFKWcwmEO85yhF9IhYxTyZ7gRmdK8iz-TxIoRsakyO0boVZjRNO1brTpGBgYAMuhOGHmuibg3wR9iIhS5D-nJMlbB00F4=), currently in press at AAPS PharmSciTech, an official journal of The American Association of Pharmaceutical Scientists.

This marks the industry's **first** pre-clinical study of **Δ8-THC nanoemulsions**, which was conducted and published in collaboration with Verdient Science, LLC.

### **Nanoemulsions Outperform Oil Solution by 19X during 1 Hour and 4X during 4 Hours After Administration:**

**![D8-THC_Trial-Completed-Poster-pic,-no-title](https://blog.sonomechanics.com/hs-fs/hubfs/D8-THC_Trial-Completed-Poster-pic%2c-no-title.jpg?width=7197&height=3981&name=D8-THC_Trial-Completed-Poster-pic%2c-no-title.jpg)**

### **Main Study Aims and Design:**

Over many years, ISM's **ultrasonic equipment** and **NanoStabilizers®** have enabled thousands of companies around the world to produce their own water-soluble liquid and powdered nano-formulations that can be infused into various finished products (beverages, edibles, water-soluble powder mixes, chewable and effervescent tablets, etc.) and significantly improve absorption profiles of the incorporated bioactive ingredients.

The main pharmacokinetic parameter of interest for most therapeutic ingredients (cannabinoids, alkaloids, terpenes, etc.) is the **rate of absorption** into the bloodstream post-administration. This rate is characterized as the "onset time", "time to maximum concentration in the bloodstream", and/or "average concentration in the bloodstream over a time window of interest".

This study was aimed at evaluating the rate of oral absorption of **Δ8-THC** formulated as two nanoemulsions: liquid translucent (made with NanoStabilizer®-LT) and powdered (made with NanoStabilizer®-LSO), and as an MCT oil solution. The study parameters were optimized for the **rate of absorption** evaluation, rather than other, less consequential parameters (absolute bioavailability comparisons, food effects, etc.).

![liquid and powdered NEs](https://blog.sonomechanics.com/hs-fs/hubfs/liquid%20and%20powdered%20NEs.jpg?width=508&height=325&name=liquid%20and%20powdered%20NEs.jpg)

### **Summary of Results:**

- During the most important first hour after administration, NanoStabilizer®-LT- and LSO-based **nanoemulsions** provided **6x** and **18.8x** greater absorption of Δ8-THC, respectively, than the MCT oil solution.
- During the extended 4-hour period after administration, NanoStabilizer- LT- and LSO-based **nanoemulsions** provided **1x** and **3.4x** greater absorption of Δ8-THC, respectively, than the MCT oil solution.
- Both nanoemulsions enabled a much more rapid **onset time** and a much shorter **time to maximum concentration** in the bloodstream (~5 min and <1 hour, respectively) than the MCT oil solution (~1 hour and 6 hours, respectively).
- The translucent **liquid** and **powdered** Δ8-THC nanoemulsions displayed remarkably **similar** properties to each other.

### **Main Conclusions:** 

- **Δ8-THC nanoemulsions** made with ISM's ultrasonic [equipment](https://www.sonomechanics.com/3600_w_industrial-scale_processor/) and [NanoStabilizers®](https://sonomechanics.myshopify.com/collections/all-in-one-nanostabilizer) allow consumers to quickly harness this cannabinoid's therapeutic effects, providing an almost immediate **onset time** and considerably **greater absorption** within time windows of interest.
- ISM's nanoemulsions of hydrophobic active ingredients (cannabinoids, alkaloids, terpenes, etc.) are advantageous for creating **fast-acting infused products**, such as beverages, edibles, water-soluble powder mixes, chewable and effervescent tablets, and many others.

[![Download Manuscript](https://no-cache.hubspot.com/cta/default/478120/b3804fb5-6058-40e8-a48f-3f2a0d096a43.png)](https://cta-redirect.hubspot.com/cta/redirect/478120/b3804fb5-6058-40e8-a48f-3f2a0d096a43)

 

Have questions? Contact ISM at 1.786.233.9255 or [contact@sonomechanics.com](mailto:contact@sonomechanics.com).

| ![NanoStabilizer_LT](https://blog.sonomechanics.com/hs-fs/hubfs/NanoStabilizer_LT.jpg?width=3412&height=2275&name=NanoStabilizer_LT.jpg) [![Buy NanoStabilizer-LT](https://no-cache.hubspot.com/cta/default/478120/263e7660-c6a9-40f9-a151-c7556f266e8f.png)](https://cta-redirect.hubspot.com/cta/redirect/478120/263e7660-c6a9-40f9-a151-c7556f266e8f) | ![NanoStabilizer_-LSO_1080x](https://blog.sonomechanics.com/hs-fs/hubfs/NanoStabilizer_-LSO_1080x.jpeg?width=1080&height=720&name=NanoStabilizer_-LSO_1080x.jpeg) [![Buy NanoStabilizer-LSO](https://no-cache.hubspot.com/cta/default/478120/db50ef07-5a9b-43d3-8e86-ddf0f49bd021.png)](https://cta-redirect.hubspot.com/cta/redirect/478120/db50ef07-5a9b-43d3-8e86-ddf0f49bd021) |
| --- | --- |

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 Topics: [Emulsion-based Products](https://blog.sonomechanics.com/blog/topic/emulsion-based-products), [General Announcements](https://blog.sonomechanics.com/blog/topic/general-announcements), [Medical Cannabis](https://blog.sonomechanics.com/blog/topic/medical-cannabis)

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