Sonomechanics Blog

Industrial Sonomechanics (ISM) was honored to participate in the 1st International Conference in Ultrasonics Food and Technology hosted by TEAGASC in Dublin, Ireland, this past week.

We extend our sincere thanks to the organizers for hosting a successful inaugural event and to all the attendees, many of whom ISM President and Chief Scientific Officer, Dr. Alexey Peshkovsky, had the pleasure of meeting throughout the conference.

We are pleased to announce the launch of All-In-One NanoStabilizer®-LSSP — the newest addition to our product line.

Building on the success of our All-In-OneNanoStabilizer®-LTand LSO, the Industrial Sonomechanics R&D team continues to push the boundaries of innovation in the production of water-soluble bioactive nanoemulsions. This new formulation is specifically designed to enable the production of water-soluble liquid and powdered kratom, kava, and mushroom extract nanoemulsions, opening new possibilities for the food, beverage, and supplements industries.

We are excited to announce that Industrial Sonomechanics (ISM) been awarded a $306,865 Phase I Small Business Innovation Research (SBIR) grant from the Department of Health and Human Services, National Institutes of Health (NIH), National Center for Complementary and Integrative Health (NCCIH).

One of the most common questions we receive from customers is about the long-term stability of nanoemulsions made with our All-In-One NanoStabilizer® systems—both the liquid (LT) and powdered (LSO) formats—when used with our ultrasonic processors (lab-, bench-, orindustrial-scale) or third-party high-pressure homogenizers. Specifically, customers want to know how well droplet sizes hold up over time, which is key to maintaining the exceptional pharmacokinetic performance (high bioavailability and short onset times) these water-soluble formulations are known for.

The answer? Incredibly well.

All-In-One NanoStabilizers® have transformed the cannabis and nutraceutical industries by simplifying the creation of permanently stable, highly bioavailable nanoemulsions. These revolutionary products are designed to work with a wide range of poorly water-soluble bioactive ingredients, including full- and broad-spectrum oils, distillates, isolates, vitamins, essential oils, terpenes, alkaloids, and many more. Compatible with both high-pressure homogenizers (HPH) and ultrasonic processors, NanoStabilizers® ensure the industry’s smallest droplet sizes, superior stability, enhanced bioavailability, and rapid onset of action for your nano-formulations.

Producing fast-acting, highly bioavailable, readily water-soluble nanoemulsions of bioactive ingredients—such as cannabis extracts, pharmaceutical and nutraceutical compounds, vitamins, essential oils, and terpenes—has become standard practice for many functional food and beverage manufacturers. Whether crafting beverages, water-based tinctures, gummies, edibles, or other infused products, the ability to reduce the onset time and enhance the bioavailability of incorporated bioactives is critical. The key to achieving these outcomes lies in formulating nanoemulsions with sub-100 nm median droplet sizes [1, 2].

Industrial Sonomechanics (ISM), a global leader in high-intensity ultrasonic technology and nano-formulations, proudly announces that its all-in-one NanoStabilizer®-LSTM has successfully passed validation and is now available to companies seeking to produce liquid and powdered water-soluble kratom formulations from mitragynine-rich extracts. Already popular with functional beverage producers for water-soluble mushroom extracts, this innovative, all-natural formulation is now accessible to kratom product manufacturers. It enables the production of highly bioavailable, clean-label water-soluble mitragynine liquids and powders, opening new opportunities in the nutraceutical and supplement markets.

We are thrilled to announce the launch of NanoStabilizer®-LSTM, the newest addition to our product line!

Building on the success of our All-In-One NanoStabilizer®-LT and LSO, the Industrial Sonomechanics R&D team continues to push the boundaries of innovation in the production of water-compatible nanoemulsions. This new cutting-edge formulation is specifically designed to help you produce water-soluble liquids and powders from mushroom extracts, opening up new possibilities for the food, beverage, and supplements industries.

The demand for water-soluble mushroom extracts is surging, driven by the growing interest in their therapeutic, health-promoting benefits. Water-soluble extracts are highly desirable due to their enhanced, rapid absorption and ease of incorporation into various consumer products such as beverages, foods, and nutritional supplements [1].

Producing water-soluble mushroom extracts in liquid or powdered forms involves two important processing steps: (1) extraction of the bioactive compounds from mushrooms and (2) their subsequent nano-emulsification to achieve aqueous solubility. Industrial Sonomechanics (ISM) has perfected these processes to ensure that our customers can manufacture the highest-quality finished products infused with water-soluble mushroom extracts. 

In March of this year, Industrial Sonomechanics (ISM) hosted a webinar, entitled "Water-Compatible Nanoemulsions: The Battle of Formulations", presented by ISM's President and Chief Scientific Officer, Dr. Alexey Peshkovsky. The video recording of this event has been posted on our YouTube channel.

The webinar generated over 100 questions, some of which were addressed by Alexey during the event. The answers to the remaining questions are provided below. If you have any additional questions, please do not hesitate to contact us or leave a comment below.