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Cannabis Research Publication in the Journal of Drug Delivery Science & Technology

[fa icon="calendar'] Sep 23, 2020 11:45:00 AM / by Iva Gyurgina posted in Emulsion-based Products, General Announcements, Medical Cannabis

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Industrial Sonomechanics® (ISM) is pleased to announce that our peer-reviewed research article, "Cannabis Extract Nanoemulsions Produced by High-intensity Ultrasound: Formulation Development and Scale-up", was recently published in the Journal of Drug Delivery Science and Technology and is now accessible online. The article compares natural and synthetic surfactant-based "water-soluble" CBD nanoemulsion formulations and describes methods used for their optimization and production with scalable Barbell Horn® Ultrasonic Technology (BHUT).

The paper describes two main types of cannabis extract nanoemulsions (natural and synthetic surfactant-based), focusing on formulation optimization procedures, production processes and droplet sizeanalysis techniques used to evaluate the results. ISM's LSP-600 processor configured in the batch-mode was used for the laboratory-scale optimization experiments, after which the process was transferred to the bench scale using our BSP-1200 processor operating in the flow-through mode. Over one million of nano-emulsified 10 mg CBD extract doses were shown to be possible to produce with one BSP-1200 unit per month. This number can be increased by the factor of five by further upgrading to our ISP-3000 processor configured in the flow-through mode.

While not referenced in the article, ISM has since introduced a product called NanoStabilizer®. This all-in-one, tasteless formulation is optimized for the production of translucent nanoemulsions with much smaller droplet sizes than could be achieved prior to its development. 

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Live Webinar: Analysis, Optimization & Production of Translucent Nanoemulsions

[fa icon="calendar'] Aug 24, 2020 10:30:00 AM / by Iva Gyurgina posted in Emulsion-based Products, General Announcements, Medical Cannabis

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Industrial Sonomechanics (ISM) is pleased to invite you to a live webinar, which will be conducted via Zoom at 3:00 pm EST on Thursday, September 10th, 2020. The webinar, entitled "Analysis, Optimization and Production of Translucent Nanoemulsions", will be presented by ISM's Research & Development Scientist, Mr. Shlomo Leibtag, and Micromeritics Instrument Corporation's Global Technical Training and Support Manager and Associate Scientist, Mr. Jack G. Saad. 

Webinar Overview  

Translucent oil-in-water nanoemulsions have become popular for the target site delivery of functional (e.g., biologically active) hydrophobic ingredients and are currently implemented by many industries, including pharmaceutical, cannabis, food & beverage, nutraceutical, chemical, alternative fuel and many more. Driven by their nanoscale (20 - 200 nm) droplet sizes, translucent oil-in-water nanoemulsions have several desirable properties: they are water-compatible, physically and chemically stable, and allow the incorporated hydrophobic ingredients to be delivered rapidly and completely.

But how does one measure nanoemulsion droplet sizes? And how can this information be utilized to optimize nanoemulsion formulations and production parameters?

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Webinar Recording and Q&As: Commercial Production of Water-Soluble THC & CBD

[fa icon="calendar'] Jul 7, 2020 10:00:00 AM / by Iva Gyurgina posted in General Announcements, Medical Cannabis

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The recording of our recent webinar, entitled "Commercial Production of Water-Soluble THC & CBD by High-Intensity Ultrasound", featuring Dr. Alexey Peshkovsky as a speaker, is now ready. The webinar, which was held on Wednesday, May 13th, 2020, had over 400 registered participants and generated close to 200 questions. Some of these questions were addressed by Alexey during the webinar, the answers to the rest are provided in this post. If you have any additional questions, please do not hesitate to contact us or leave a comment below. 

 

 

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Live Webinar: Commercial Production of Water-Soluble THC & CBD by High-Intensity Ultrasound

[fa icon="calendar'] May 5, 2020 2:30:08 PM / by Iva Gyurgina posted in General Announcements, Medical Cannabis

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Industrial Sonomechanics (ISM) is pleased to invite you to a live webinar, which will be conducted via Zoom at 3:00 pm EST on Wednesday, May 13th, 2020. The webinar, entitled "Commercial Production of Water-Soluble THC and CBD Nanoemulsions with High-Intensity Ultrasound", will be presented by ISM's president and Chief Scientific Officer, Dr. Alexey Peshkovsky. If you are interested in producing your own cannabis extract nanoemulsions (water-soluble CBD and THC) that improve cannabinoid absorption and can be offered as tinctures, powders and tablets or infused into beverages, edibles and topicals, please join us for this 1-hour event!

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2020 White Label Expo Highlights: Water-Soluble CBD on the Rise

[fa icon="calendar'] Mar 18, 2020 12:10:33 PM / by Iva Gyurgina posted in General Announcements, Medical Cannabis

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Last month, Industrial Sonomechanics ( ISM ) participated in the 2020 White Label Expo in Las Vegas, NV. This two-day event gathered thousands of exhibitors, speakers and CBD product suppliers under one roof, demonstrating the rapid growth of the cannabis industry. We are excited about the tremendous success of the show and thankful to those of you who were able to join us at our booth and attended Dr. Peshkovsky's presentation.  
 
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6 Frequently Asked Questions About All-In-One NanoStabilizer®

[fa icon="calendar'] Feb 3, 2020 11:48:04 AM / by Alexey Peshkovsky, Ph.D. posted in Emulsion-based Products, Medical Cannabis

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For the past two years, many businesses have been using our all-in-one NanoStabilizer® to convert their cannabis extracts and other hydrophobic bio-actives into water-compatible, stable, translucent nanoemulsions. Most commonly, the conversion is done in order to enhance the bioavailability and accelerate the onset of action of cannabinoids and to infuse beverages without making them cloudy. Designed to work with Industrial Sonomechanics ultrasonic liquid processors, NanoStabilizer® requires no formulation development experience and is compatible with a wide range of bio-actives, including most types of cannabis extracts and isolates, pharmaceutical ingredients, vitamins, essential oils, terpenes, etc. In this post, I provide answers to some of the most commonly asked questions about this popular product.

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ISM will Present at the 2020 White Label USA Expo in Las Vegas, NV

[fa icon="calendar'] Jan 13, 2020 10:30:00 AM / by Iva Gyurgina posted in General Announcements, Medical Cannabis

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Industrial Sonomechanics ( ISMis pleased to announce its participation  in the 2020 White Label USA Expo , taking place in Las Vegas, NV, on February 26 - 27, 2020. If you are interested in producing your own "water-soluble" CBD or THC, please come by our booth #115, where s everal specialists will be available to demonstrate our ultrasonic processors and NanoStabilizer® - an all-in-one blend of tasteless food-grade (GRAS) carrier oils, emulsifiers and preservatives . See how this turn-key technology makes it easy to produce  highly translucent, permanently stable and fully water-compatible  cannabis extract nanoemulsions without having to go through formulation development, processing parameter optimization or any other type of R&D. 
 
At the event, ISM's President and Chief Scientific Officer, Dr. Alexey Peshkovsky, will also deliver a keynote presentation, entitled "Water-Soluble" CBD and THC: Ultrasonic Production of Cannabis Extract Nanoemulsions". 
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Presentation Recording, 2019 Cannabis Drinks Expo, San Francisco, CA

[fa icon="calendar'] Dec 3, 2019 9:30:00 AM / by Iva Gyurgina posted in Emulsion-based Products, General Announcements, Medical Cannabis

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We are happy to announce that the recording of Dr. Alexey Peshkovsky's 2019 Cannabis Drinks Expo keynote presentation is now ready. In his talk, entitled "Water-compatible cannabis extract nanoemulsions: benefits, formulation development and production methodology", ISM President & Chief Scientific Officer covered several topics critical to the cannabis-infused beverage industry.

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How to Formulate Cannabis Extract Nanoemulsions with a Long Shelf Life

[fa icon="calendar'] Oct 8, 2019 9:30:00 AM / by Shlomo Leibtag posted in Emulsion-based Products, Medical Cannabis

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One of the primary concerns when formulating oil-in-water (O/W) nanoemulsions is the stability of the finished product. Destabilization of an O/W nanoemulsion can occur due to several physical, chemical or biological processes that deteriorate its quality over time. Understanding and avoiding these processes is paramount to ensuring that products based on cannabis extract nanoemulsions (a.k.a. "water-soluble" CBD and THC) have a long and predictable shelf-life. In this post, common nanoemulsion destabilization pathways will be described, along with the most effective strategies to avoid them.

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ISM will Present at the 2019 CannaCon Expo in Springfield, MA

[fa icon="calendar'] Aug 22, 2019 10:02:56 AM / by Iva Gyurgina posted in General Announcements, Medical Cannabis

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We are happy to announce that Industrial Sonomechanics ( ISM) will participate in the 2019 CannaCon Expo and Conference in Springfield, MA, which will take place on August 23 - 24th, 2019. At the event's seminar, ISM's President and Chief Scientific Officer, Dr. Alexey Peshkovsky, will deliver a presentation entitled "Turn-Key Ultrasonic Technology for the Production of Translucent “Water-Soluble” Cannabis Extract Nanoemulsions"
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