Sonomechanics Blog

Industrial Sonomechanics® (ISM) has recently completed a groundbreaking pre-clinical pharmacokinetic study, comparing two orally administered Δ8-THC nanoemulsions (liquid and powdered) with a Δ8-THC solution in MCT oil. The results demonstrate considerable advantages of nanoemulsions produced with ISM's ultrasonic equipment and NanoStabilizers®, and are detailed in our latest manuscript, currently in press at AAPS PharmSciTech, an official journal of The American Association of Pharmaceutical Scientists.

This marks the industry's first pre-clinical study of Δ8-THC nanoemulsions, which was conducted and published in collaboration with Verdient Science, LLC.

We are excited to announce that Industrial Sonomechanics (ISM) will participate in the 2023 New England Cannabis Convention (NECANN) taking place on March 12th, 2023,  in Boston, MA. 

At this event, ISM President and Chief Scientific Officer, Dr. Alexey Peshkovsky, will deliver a keynote presentation entitled: "Water-Soluble" Cannabinoids, Alkaloids and Other Bioactives: Ultrasonic Production of Liquid and Powdered Nano-Formulations."

If you are interested in learning how to formulate and manufacture cannabis, kratom and other bioactives in the form of a water-soluble liquid or powder, please come to Dr. Peshkovsky's talk. 

We are excited to announce that Industrial Sonomechanics (ISM) will participate in the 2022 Wonderland event, taking place on November 3rd - 5th, 2022 in Miami, FL. At this event, ISM's President and Chief Scientific Officer, Dr. Alexey Peshkovsky, will join a panel discussion entitled: "Lab Science Behind the Magic". If you are interested in learning how to extract and formulate bioactive ingredients as water-soluble liquids or powders, please join us at this world's leading psychedelic event. 

We are excited to announce that Industrial Sonomechanics (ISM) will participate in the MJBizCon 2022, taking place on November 15 - 18, 2022, in Las Vegas, Nevada. 

At this event, our team will be showcasing ultrasonic processors (actually running them!), accessories & spare parts, NanoStabilizer® products and finished nano-formulations, so bring your team and join us at this largest cannabis convention of the year!

If you are interested in formulating and producing your own water-soluble liquid and powdered cannabis, kratom and/or other bioactives, please come see us at Booth 7937. 

We are excited to announce that Industrial Sonomechanics (ISM) will participate in the 2022 The Delta 8 + Conversions Expo in Partnership with The CBD Expo, taking place on October 6 - 7, 2022, in Orlando, FL. 

At this event, ISM President and Chief Scientific Officer, Dr. Alexey Peshkovsky, will deliver a keynote presentation entitled: "Water-Soluble" Cannabis, Kratom and Other Bioactives: Ultrasonic Production of Liquid and Powdered Nano-Formulations. 

If you are interested in learning how to formulate and manufacture cannabis, kratom and other bioactives in the form of a water-soluble liquid or powder, please come to Dr. Peshkovsky's talk. 

Benefits include significantly faster throughput, less downtime, and lower total cost of ownership.

Industrial Sonomechanics, LLC (ISM) is happy to announce the commercial availability of several new large-capacity in-line filtration products, which increase the efficiency of the nanoemulsion production process and lower the associated cost. 

Filtering is key to nanoemulsion production

Filtration is a necessary post-processing step of ultrasonic nano-emulsification—a process that converts cannabis extracts and/or other hydrophobic bioactives into a water-compatible form. This new integrated unit removes microorganisms (sterilization), dust, titanium particles, and any leftover plant matter while making filtration convenient and highly scalable.

At 1:00 pm EST on June 28th, 2022, please join us for a YouTube podcast with a live Q&A session. This event, entitled "Make and Measure the Potency of Cannabis Extract Nanoemulsions", is a collaboration project between Industrial Sonomechanics (ISM) and Orange Photonics, where Dr. Alexey Peshkovsky (ISM) and Mr. Dylan Wilks (Orange Photonics) will discuss:

1. ISM's ultrasonic technology and NanoStabilizer® formulations used to produce water-soluble cannabis extract nanoemulsions in the forms of translucent liquids, powders, and quick-disintegrating tablets.

2. Principles of Orange Photonics' Light Lab liquid chromatography technology used to measure the potency of liquid and powdered water-soluble cannabis extract nanoemulsions, including detection limits for various cannabinoids.

3. Best ways to prepare samples comprising various nanoemulsion types for accurate cannabinoid content analysis.

4. Typical reasons for and ways to avoid inconsistent or diminishing cannabinoid potency results in nanoemulsions.

5. Benefits of having a Light Lab cannabis analyzer in-house.

We will be chatting with our viewers throughout the presentation. If interested, please join the conversation at 1:00 pm EST on June 28th, 2022!

Nutraceuticals World recently interviewed our President and Chief Scientific Officer, Dr. Alexey Peshkovsky, for an article covering the topic of nanoemulsion innovations in hemp and cannabis product development.

To read the full story and learn more about what we have been working on in the nutraceuticals space please follow this link. 

The production of water-soluble nanoemulsions has been a growing segment of the cannabis and nutraceuticals markets. These products manifest themselves in terms of accelerated onset time, high bioavailability, consistent effect, and precise and reproducible therapeutic dosing, as shown by recent pre-clinical studies.

In March of this year, Industrial Sonomechanics (ISM) hosted a webinar, entitled "Water-Compatible Nanoemulsions: The Battle of Formulations", presented by ISM's President and Chief Scientific Officer, Dr. Alexey Peshkovsky. The video recording of this event has been posted on our YouTube channel.

The webinar generated over 100 questions, some of which were addressed by Alexey during the event. The answers to the remaining questions are provided below. If you have any additional questions, please do not hesitate to contact us or leave a comment below. 

If you want to produce cannabis extract nanoemulsions in water-soluble powder form, look no further than Industrial Sonomechanics’ (ISM) new offering — the tasteless, all-natural and organic All-In-One NanoStabilizer®-LSO formulation. Building on the tremendous success of our All-In-One NanoStabilizer®-LT introduced in 2018, the ISM team is at it again as it pushes the envelope of innovation in the production of water-compatible nanoemulsions.
Over the past year, we have experienced significant interest from customers for a flexible, yet cost-effective method to make a finished nanoemulsion in powder form that reconstitutes back into a liquid nanoemulsion upon contact with water. The creation of NanoStabilizer®-LSO now makes it possible for companies to produce such water-soluble powders from their active ingredients (CBD, Delta 9 THC, Delta 8 THC, essential oils, vitamins, nutraceuticals, etc.), bringing their branding and application ideas to life.