Sonomechanics Blog

One of the most common questions we receive from customers is about the long-term stability of nanoemulsions made with our All-In-One NanoStabilizer® systems—both the liquid (LT) and powdered (LSO) formats—when used with our ultrasonic processors (lab-, bench-, orindustrial-scale) or third-party high-pressure homogenizers. Specifically, customers want to know how well droplet sizes hold up over time, which is key to maintaining the exceptional pharmacokinetic performance (high bioavailability and short onset times) these water-soluble formulations are known for.

The answer? Incredibly well.

All-In-One NanoStabilizers® have transformed the cannabis and nutraceutical industries by simplifying the creation of permanently stable, highly bioavailable nanoemulsions. These revolutionary products are designed to work with a wide range of poorly water-soluble bioactive ingredients, including full- and broad-spectrum oils, distillates, isolates, vitamins, essential oils, terpenes, alkaloids, and many more. Compatible with both high-pressure homogenizers (HPH) and ultrasonic processors, NanoStabilizers® ensure the industry’s smallest droplet sizes, superior stability, enhanced bioavailability, and rapid onset of action for your nano-formulations.

Producing fast-acting, highly bioavailable, readily water-soluble nanoemulsions of bioactive ingredients—such as cannabis extracts, pharmaceutical and nutraceutical compounds, vitamins, essential oils, and terpenes—has become standard practice for many functional food and beverage manufacturers. Whether crafting beverages, water-based tinctures, gummies, edibles, or other infused products, the ability to reduce the onset time and enhance the bioavailability of incorporated bioactives is critical. The key to achieving these outcomes lies in formulating nanoemulsions with sub-100 nm median droplet sizes [1, 2].

Industrial Sonomechanics (ISM), a global leader in high-intensity ultrasonic technology and nano-formulations, proudly announces that its all-in-one NanoStabilizer®-LSTM has successfully passed validation and is now available to companies seeking to produce liquid and powdered water-soluble kratom formulations from mitragynine-rich extracts. Already popular with functional beverage producers for water-soluble mushroom extracts, this innovative, all-natural formulation is now accessible to kratom product manufacturers. It enables the production of highly bioavailable, clean-label water-soluble mitragynine liquids and powders, opening new opportunities in the nutraceutical and supplement markets.

We are thrilled to announce the launch of NanoStabilizer®-LSTM, the newest addition to our product line!

Building on the success of our All-In-One NanoStabilizer®-LT and LSO, the Industrial Sonomechanics R&D team continues to push the boundaries of innovation in the production of water-compatible nanoemulsions. This new cutting-edge formulation is specifically designed to help you produce water-soluble liquids and powders from mushroom extracts, opening up new possibilities for the food, beverage, and supplements industries.

Industrial Sonomechanics (ISM) is excited to announce our participation in the 2024 MJBizCon, happening this December in Las Vegas, NV! Join us at booth #4635 to explore our ultrasonic technology, including our turn-key systems used for extraction and nano-emulsification, and an array of formulation solutions designed to meet the evolving needs of our cannabis and nutraceutical customers.

Our team will be showcasing ISM's high-amplitude ultrasonic processors, new NanoStabilizer® products, accessories, and finished nano-formulations. Whether you are looking to extract from lion's mane, reishi, chaga mushrooms, or to create water-soluble liquid or powdered formulations for cannabis, kratom, or other bioactives, this is the ideal opportunity to discover how ISM can support your business goals.

To make the most of your visit, we encourage you to schedule a meeting in advance with our experts: 

Schedule a Meeting with ISM at MJBizCon

Wine is highly susceptible to oxygen exposure, which can dramatically affect its quality and longevity. The presence of dissolved oxygen can initiate oxidation, altering the wine's sensory characteristics and diminishing its overall value. As a result, the ability to reduce oxygen levels in wine has become a critical focus for winemakers and researchers alike.

In this blog post we will dive into this age-old problem and discuss how Industrial Sonomechanics' (ISM) cutting-edge ultrasonic degassing technology can be used as an innovative solution while setting new standards for wine preservation.

The Problem: Dissolved Oxygen-Induced Oxidation in Wine

Dissolved oxygen is both a friend and a foe in winemaking. While small amounts of oxygen can be beneficial during certain stages of the winemaking process, such as micro-oxygenation to soften tannins, excessive exposure during storage, aging, or bottling can lead to unwanted oxidation. Oxidation can cause the wine to lose its vibrant color, develop off-flavors, and otherwise deteriorate in quality. White wines are particularly sensitive to oxygen, but red wines are not immune, as oxidation can cause the loss of fruity aromas and the development of stale or sherry-like notes [1, 2].

The challenge for winemakers is to manage oxygen exposure throughout the entire winemaking process, from fermentation to the final bottling. Even small amounts of oxygen can compromise the wine's integrity, leading to significant economic losses and a negative impact on brand reputation.

Industrial ultrasonic processors are vital tools for applications like nano-emulsification, cell lysis, nanoparticle dispersion, and nano-crystallization—processes that are widely utilized across numerous industries. Choosing the right system is crucial for achieving superior results and ensuring uninterrupted production, at large volumes on the plant floor.

In this blog post, we will explore the key features that drive performance, helping you make an informed decision and ensuring your ultrasonic processor meets the specific demands of your application.

We are thrilled to announce that Industrial Sonomechanics (ISM) has been granted a new patent by the United States Patent and Trademark Office!

This achievement marks a significant expansion of ISM's intellectual property portfolio. The patent specifically covers several new embodiments of our groundbreaking high-amplitude Barbell Horns® technology, which are crucial to the superior performance and efficiency of our ultrasonic processors.

Further details on our Barbell Horn designs and the new patent are provided below.

The demand for water-soluble mushroom extracts is surging, driven by the growing interest in their therapeutic, health-promoting benefits. Water-soluble extracts are highly desirable due to their enhanced, rapid absorption and ease of incorporation into various consumer products such as beverages, foods, and nutritional supplements [1].

Producing water-soluble mushroom extracts in liquid or powdered forms involves two important processing steps: (1) extraction of the bioactive compounds from mushrooms and (2) their subsequent nano-emulsification to achieve aqueous solubility. Industrial Sonomechanics (ISM) has perfected these processes to ensure that our customers can manufacture the highest-quality finished products infused with water-soluble mushroom extracts.