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Live Webinar: Commercial Production of Water-Soluble THC & CBD by High-Intensity Ultrasound

[fa icon="calendar"] May 5, 2020 2:30:08 PM / by Iva Gyurgina

Webinar by Dr Alexey Peshkovsky - Commercial Production of Water-Soluble THC and CBD by High-Intensity Ultrasound, 05-13-20

Industrial Sonomechanics (ISM) is pleased to invite you to a live webinar, which will be conducted via Zoom at 3:00 pm EST on Wednesday, May 13th, 2020. The webinar, entitled "Commercial Production of Water-Soluble THC and CBD Nanoemulsions with High-Intensity Ultrasound", will be presented by ISM's president and Chief Scientific Officer, Dr. Alexey Peshkovsky. If you are interested in producing your own cannabis extract nanoemulsions (water-soluble CBD and THC) that improve cannabinoid absorption and can be offered as tinctures, powders and tablets or infused into beverages, edibles and topicals, please join us for this 1-hour event!

"Commercial Production of Water-Soluble THC and CBD Nanoemulsions with High-Intensity Ultrasound"

Date: Wednesday, May 13th, 2020
Time: 3:00 PM EST
Duration: 1 hour

Register Here

Key Takeaways:

  1. Achieving efficient, reproducible and predictable absorption of cannabinoids into the bloodstream has been and continues to be a major obstacle in the industry.
  2. Traditional and historical methods of introducing cannabis into the body have been unpredictable in terms of bioavailability, timely onset of action and safety.
  3. Cannabis extracts are NOT soluble in water, therefore, edibles and similar products taken by the mouth are slow and inefficient.
  4. Translucent nanoemulsions of cannabinoids solve for these deficiencies, creating a rapid, predictable and reproducible effect.
  5. High-intensity ultrasound has proven to be a superior solution for producing translucent nanoemulsions that can be infused into beverages without changing their appearance.


oral/digestive administration route

Traditional oral administration of cannabinoids (e.g., as edibles or oil gel capsules), while safer and more discreet than smoking or vaping, suffers from low bioavailability, delayed onset of action and poor reproducibility. Being insoluble in water, cannabinoids cannot undergo gastrointestinal absorption until they are incorporated into mixed micelles, which are slowly formed in the small intestine during hydrolysis of co-administered triglycerides. While this step is necessary to allow cannabinoids to migrate to the intestinal absorptive cells, it drastically delays and diminishes the efficiency and reproducibility of the absorption process.

Pharmaceutical industry's most successful method for overcoming similar challenges is to formulate hydrophobic bio-actives as oil-in-water nanoemulsions, which are kinetically stable, known to provide exceptional therapeutic effects, and allow the incorporated bio-actives to be absorbed rapidly and completely. This presentation will demonstrate how the same approach can be applied to the cannabis industry.

Powdered and liquid NE dosing animationCommercial-scale production of translucent cannabinoid nanoemulsions (water-soluble CBD and THC) requires the use of an optimized formulation and a high-intensity ultrasonic processor, yielding stable water-based concentrates that are readily infused into beverages without compromising their appearance (e.g., optical clarity). Since aqueous dispersions of droplets in translucent nanoemulsions closely mimic mixed micelles, they rapidly migrate to the intestinal absorptive cells, bypassing the slow in-situ micelle formation process. Pre-clinical pharmacokinetic study results will be presented, showing significant onset of action acceleration and bioavailability enhancement of THC administered as a translucent nanoemulsion-infused beverage versus a traditional oil gel capsule.

If you have any questions, please do not hesitate to contact us or leave a comment below.

Topics: General Announcements, Medical Cannabis

Iva Gyurgina

Written by Iva Gyurgina

Iva Gyurgina is the Director of Marketing and Customer Relations at ISM. She is responsible for creating and delivering ISM’s marketing materials and managing correspondence with ISM clients. Iva holds a B.S. in Finance and Management Information Systems from Seton Hall University as well as an M.B.A. in Marketing and Management from University of Connecticut. Prior to joining ISM, Iva was a Tennis Professional and has managed tennis clubs’ programs in several locations in NY. She has also worked in wealth management, technology and pharmaceuticals industries. Iva has proven experience in building customer relationships and delivering marketing strategies.