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Why Sterile-Filter Water-Compatible Cannabis Extract Nanoemulsions?

[fa icon="calendar'] Dec 3, 2018 10:23:58 AM / by Alexey Peshkovsky, Ph.D. posted in Medical Cannabis, Emulsion-based Products

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Sterile filtration is an important post-processing step of ultrasonic nano-emulsification - a process that converts cannabis extracts and/or other hydrophobic bioactives into a water-compatible form. In this article, I will summarize the steps of the nano-emulsification process carried out with BHUT-based ultrasonic equipment and NanoStabilizer™, list the main advantages of the resulting water-compatible nanoemulsions, and explain why sterile filtration is always necessary at the end. Answers to several FAQs will also be provided.

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ISM to Present at Marijuana for Medical Professionals Conference

[fa icon="calendar'] Oct 8, 2018 2:36:05 PM / by Iva Gyurgina posted in General Announcements, Medical Cannabis

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We are excited to announce that ISM will participate in 2018 Marijuana for Medical Professionals conference in Denver, CO, taking place on October 14 - 16, 2018, at the Marriott Hotel Denver Tech Center.

At the conference, ISM President and Chief Scientific Officer, Dr. Alexey Peshkovsky, will be giving a talk, entitled "How and Why to Make Cannabis "Water-Soluble"." 

If you are interested in learning about translucent, water-compatible nanoemulsions of cannabis extracts that can be infused into beverages, edibles and topicals, resulting in enhanced bioavailability and shortened onset of therapeutic action, please come see Dr. Peshkovsky's presentation! 

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Managing the Bitter Taste of Cannabis-Infused Beverages

[fa icon="calendar'] Sep 18, 2018 9:00:00 AM / by Alexey Peshkovsky, Ph.D. posted in Medical Cannabis, Emulsion-based Products

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We are frequently asked how to minimize the bitter taste of products made with cannabis extract nanoemulsions (a.k.a., water-soluble CBD and THC). Infusing beverages with CBD and/or THC-containing translucent nanoemulsions (ideally, averaging ~20 nanometers in droplet size diameter) offers a very convenient, discrete and effective consumption method. The infusion does not change the original appearance of the beverages while instantly enabling them to provide a very rapid onset of action and high bioavailability of cannabinoids as well as of any other incorporated active ingredients. With this pharmacokinetic profile, the experience a lot more similar to consuming an alcoholic beverage than a typical cannabis-containing edible, which provides a myriad of attractive options for the vendors and consumers. In many cases, however, the infusion results in a bitter taste, which can range in intensity from virtually undetectable to quite unpleasant and makes it important to understand and manage.

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Webcast Recording and Q&As: Cannabis Oil Nano-Emulsification & Extraction

[fa icon="calendar'] Jun 25, 2018 7:00:00 AM / by Iva Gyurgina posted in General Announcements, Medical Cannabis

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The recording of Cannabis Tech Media's recent webcast on Ultrasonic Liquid Processing for Cannabis Oil Nano-Emulsification and Extraction, featuring guest speaker Dr. Alexey Peshkovsky, President and Chief Scientific Officer of Industrial Sonomechanics, is now ready. The webcast, which was held on Thursday, May 17th, 2018, had over 300 registered participants and generated close to 150 questions. Some of these questions were addressed by Alexey during the webcast. The answers to the rest are provided in this post. If you have any additional questions, please do not hesitate to contact us or leave a comment below.

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Live Webcast on Cannabis Oil Nano-Emulsification and Extraction

[fa icon="calendar'] May 16, 2018 8:30:00 AM / by Iva Gyurgina posted in General Announcements, Medical Cannabis

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We are happy to announce that Dr. Alexey Peshkovsky, President & Chief Scientific Officer of Industrial Sonomechanics (ISM), will be the guest speaker at CannabisTech Media's live webcast, presenting ISM's high-intensity ultrasonic technology for cannabis oil nano-emulsification and extraction. Interested in making or using water-soluble cannabis extracts? Join us on Thursday, May 17th, 2018 at 11:00 am (MDT). 

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ISM Will Be Exhibiting at the NYC Cannabis World Congress & Business Expo

[fa icon="calendar'] May 8, 2018 8:02:00 AM / by Iva Gyurgina posted in General Announcements, Medical Cannabis

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We are happy to announce that ISM will participate in the Cannabis World Congress and Business Exposition in New York, NY. The conference will take place from May 30th to June 2nd, 2018, at the Jacob K. Javits Convention Center located in Midtown Manhattan. If you are interested in making translucent cannabis extract nanoemulsions (water-soluble CBD and THC that can be infused into beverages, edibles, topicals, etc.) with enhanced bioavailability and a rapid onset of action, please come see us at booth 519! We will be exhibiting all our ultrasonic liquid processors as well as our new NanoStabilizer™. We will also bring along some nanoemulsion samples made with our technology. 

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All-In-One NanoStabilizer™ Simplifies Making Water-Soluble CBD and THC

[fa icon="calendar'] Apr 10, 2018 9:00:00 AM / by Iva Gyurgina posted in Medical Cannabis, Emulsion-based Products

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You do not have to be a scientist to make high-quality water-soluble CBD and THC! Industrial Sonomechanics' customers no longer need to develop their own formulations and production protocols for cannabis extract nanoemulsions. We are pleased to announce the launch of a new product: all-in-one NanoStabilizer™. This convenient product can tremendously simplify the ultrasonic production of high-quality, translucent nanoemulsions of bio-active ingredients such as cannabis extracts. This product is designed to work in conjunction with our laboratory, bench and industrial ultrasonic processors, and comes with detailed, easy-to-follow instructions.

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Chapter Published in a New Book on Ultrasonic Food Processing

[fa icon="calendar'] Mar 31, 2018 3:32:58 PM / by Iva Gyurgina posted in General Announcements, Food & Beverage

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Industrial Sonomechanics (ISM) is pleased to announce the recent publication of a book entitled "Ultrasound: Advances in Food Processing and Preservation," edited by Dr. Daniela Bermudez-Aguirre (Academic Press, 2017). The book provides an extensive overview of the potential of ultrasound technology to drive innovation in the field of food processing and preservation, and features a chapter by ISM's co-founder, President and Chief Scientific Officer, Dr. Alexey Peshkovsky. This chapter, entitled "From Research to Production: Overcoming Scale-Up Limitations of Ultrasonic Processing," explains how ultrasonic processing can be directly scaled up from laboratory to production environments while maintaining reproducible, high-quality results.

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ISM Will Be Exhibiting at the World Medical Cannabis Conference & Expo

[fa icon="calendar'] Jan 29, 2018 8:10:00 AM / by Iva Gyurgina posted in General Announcements, Medical Cannabis

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We are happy to announce that ISM will participate in the 2018 World Medical Cannabis Conference & Expo in Pittsburgh, PA. The conference will take place from April 12 to 14, 2018, at the David L. Lawrence Convention Center located in downtown Pittsburgh. If you are interested in making translucent cannabis extract nanoemulsions ("water-soluble" CBD and THC that can be infused into beverages, edibles, topicals, etc.) with enhanced bioavailability and a rapid onset of action, please come see us at booth 515!

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Ultrasonic Nano-Crystallization of Salsalate for Improved Bioavailability

[fa icon="calendar'] Dec 14, 2017 10:00:00 AM / by Shlomo Leibtag posted in Wet Milling and Dispersing

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Salsalate is part of a class of naturally occurring chemicals known as salicylates, which are among the oldest prescribed medicinal anti-inflammatories [1]. The most common salicylate is acetylsalicylic acid (ASA) (coined Aspirin by Bayer in 1899) and its main biochemical function is the reduction of inflammation and fever via the inhibition of cyclooxygenase enzymes (COX) [2]. Over the last century, it has been suggested that salicylates could have other medicinal benefits, specifically in the treatment of mild cases of diabetes [3, 4, 7]. Aspirin has been administered to patients with pre-diabetes/obesity in order to hinder the evolution of the disease. Unfortunately, inhibition of COX by Aspirin results in abnormalities in bleeding, platelet aggregation and gastric regulation [8, 9]. In retribution, medical practitioners have looked to salsalate [14] to provide treatment to diabetes patients as it has similar anti-inflammatory properties to Aspirin yet has been shown to be significantly less gut damaging [10]. To maximize the bioavailability of the drug and promote effective therapy, nano-crystallization of salsalate clusters must be performed to reduce their median particle size below one micron [12]. 

High-intensity ultrasonic liquid processing provides a simple means for such particle comminution. In this post we demonstrate how salsalate crystals can be brought to sub-micron median particle sizes by ultrasonic milling with Industrial Sonomechanics bench-scale processor, BSP-1200, configured in the flow-through mode. 

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