Sonomechanics Blog

Industrial Sonomechanics (ISM) is pleased to invite you to a live webinar, which will be conducted via Zoom at 3:00 pm EST on Wednesday, March 24th, 2021. The webinar, entitled "Water-Compatible Nanoemulsions: The Battle of Formulations", will be presented by ISM's president and Chief Scientific Officer, Dr. Alexey Peshkovsky.

If you are in the market to produce water-compatible nanoemulsions (water-soluble CBD and THC) you might be confused by the verbiage and terms in the marketplace such as: liquid or powdered nanoemulsions, microemulsions, liposomes, active ingredient concentrations, powder reconstitution, translucency, particle sizes, bioavailability, and onset of action. 

If you are trying to figure out the best solution for your company but don’t have all the tools to make informed comparisons and decisions relative to water-compatible nanoemulsions, then this webinar is for you.

Industrial Sonomechanics® (ISM) is pleased to announce that our peer-reviewed research article, "Cannabis Extract Nanoemulsions Produced by High-intensity Ultrasound: Formulation Development and Scale-up", was recently published in the Journal of Drug Delivery Science and Technology and is now accessible online. The article compares natural and synthetic surfactant-based "water-soluble" CBD nanoemulsion formulations and describes methods used for their optimization and production with scalable Barbell Horn^® Ultrasonic Technology (BHUT).

The paper describes two main types of cannabis extract nanoemulsions (natural and synthetic surfactant-based), focusing on formulation optimization procedures, production processes and droplet sizeanalysis techniques used to evaluate the results. ISM's LSP-600 processor configured in the batch-mode was used for the laboratory-scale optimization experiments, after which the process was transferred to the bench scale using our BSP-1200 processor operating in the flow-through mode. Over one million of nano-emulsified 10 mg CBD extract doses were shown to be possible to produce with one BSP-1200 unit per month. This number can be increased by the factor of five by further upgrading to our ISP-3000 processor configured in the flow-through mode.

While not referenced in the article, ISM has since introduced a product called NanoStabilizer^®. This all-in-one, tasteless formulation is optimized for the production of translucent nanoemulsions with much smaller droplet sizes than could be achieved prior to its development. 

Industrial Sonomechanics (ISM) is pleased to invite you to a live webinar, which will be conducted via Zoom at 3:00 pm EST on Thursday, September 10th, 2020. The webinar, entitled "Analysis, Optimization and Production of Translucent Nanoemulsions", will be presented by ISM's Research & Development Scientist, Mr. Shlomo Leibtag, and Micromeritics Instrument Corporation's Global Technical Training and Support Manager and Associate Scientist, Mr. Jack G. Saad. 

Webinar Overview  

Translucent oil-in-water nanoemulsions have become popular for the target site delivery of functional (e.g., biologically active) hydrophobic ingredients and are currently implemented by many industries, including pharmaceutical, cannabis, food & beverage, nutraceutical, chemical, alternative fuel and many more. Driven by their nanoscale (20 - 200 nm) droplet sizes, translucent oil-in-water nanoemulsions have several desirable properties: they are water-compatible, physically and chemically stable, and allow the incorporated hydrophobic ingredients to be delivered rapidly and completely.

But how does one measure nanoemulsion droplet sizes? And how can this information be utilized to optimize nanoemulsion formulations and production parameters?

Industrial Sonomechanics (ISM) is pleased to invite you to a live webinar, which will be conducted via Zoom at 3:00 pm EST on Wednesday, May 13th, 2020. The webinar, entitled "Commercial Production of Water-Soluble THC and CBD Nanoemulsions with High-Intensity Ultrasound", will be presented by ISM's president and Chief Scientific Officer, Dr. Alexey Peshkovsky. If you are interested in producing your own cannabis extract nanoemulsions (water-soluble CBD and THC) that improve cannabinoid absorption and can be offered as tinctures, powders and tablets or infused into beverages, edibles and topicals, please join us for this 1-hour event!