This is a second article in the series on the principles of formulating water-compatible cannabis extracts and isolates, also known as water-soluble CBD and THC. The first article showed multiple advantages of nanoemulsions over the other two water-compatible formulation classes: microemulsions and liposomes. Here I will demonstrate the importance of using a carrier oil in your cannabis extract or isolate nanoemulsion. I will also explain how to select the proper carrier oil among the available choices.
Industrial Sonomechanics is launching a series of blog posts dedicated to describing the main principles of developing water-compatible cannabis extract formulations, also known as water-soluble CBD and THC. As explained in our earlier blog post, since medical marijuana extracts are oils and, as such, not soluble in water, they have to be specially formulated in order to become water-compatible and acquire the appearance of being water-soluble. There are three formulation classes that can provide this property: microemulsions, liposomes and nanoemulsions.
The cannabis (marijuana, hemp) plant has been used for medicinal purposes for millennia. In addition to terpenes and flavonoids, over 100 types of therapeutically active compounds known as cannabinoids have been identified in these plants . The two most important and well-known cannabinoids are tetrahydrocannabinol (THC) and cannabidiol (CBD) . Cannabinoids have the ability to directly and/or indirectly affect receptors in our cells because they mimic endocannabinoids produced by our own bodies endogenously, for example, in response to injury .
Cannabinoids (CBD, THC, etc.) are hydrophobic (water-hating) oily substances and, as such, not water-soluble. They can, however, be formulated to be water-compatible and appear water-soluble.
The term "water-soluble CBD" has lately been extensively used throughout the medical cannabis industry. "Water-soluble" means able to homogeneously incorporate into water by separating into molecules or ions (dissolve like sugar, alcohol or salt). Oily substances, however, are repelled by water, which forces them to stay separate from it.
Medicinal uses of the cannabis plant (e.g., medical marijuana, hemp) have now been legalized in most US states. In addition to terpenoids and flavonoids, the plant may contain over 85 different types of therapeutically active compounds known as cannabinoids, the main two of which are tetrahydrocannabinol (THC) and cannabidiol (CBD). In recent years, medications based on concentrated cannabis extracts have become popular because they allow many routes of administration that are preferable to smoking the plant itself.